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A 60-year-old man has a painful right knee and a slightly enlarged spleen. Hematology results include:
|
test |
result |
|
hemoglobin |
15 g/dL (150 g/L) |
|
absolute neutrophil count |
10.0 x 103/μL (10.0 x 109/L) |
|
platelet count |
900×103/μL (900 x 109/L) |
|
uncorrected retic count |
1% |
|
morphology |
normal red cell morphology and indices a slight increase in bands rare metamyelocyte and myelocyte giant and bizarre-shaped platelets |
This is most compatible with:
The type of bleeding that is the most characteristic in patients with platelet disorders is:
When reviewing platelet morphology on a blood smear, the presence of giant platelets is noted. This may indicate:
A patient with multimer pattern that has all bands present but in decreased concentrations would be diagnosed with:
Which characteristic of Bernard-Soulier syndrome helps distinguish it from von Willebrand disease?
Which of the following characteristics are common between Hěrmanský-Pudlák and Chédiak-Higashi syndromes?
Patients with Wiscott-Aldrich syndrome present with:
When evaluating a patient for von Willebrand disorder, the ABO blood type that has the lowest level of vWF is:
Which subtype of von Willebrand disease is the most common?
Which of the following types of von Willebrand disease should not be treated with DDAVP?
TTP presents with a pentad of symptoms that does not include:
A 40-year-old female has pinpoint hemorrhages on her legs, with an Hct of 43% and a platelet count of 19 x 103/μL (19 x 109/L). Steroids fail to increase platelet count. The patient’s diagnosis is:
A 60-year-old female presents with blurred vision, confusion, and petechiae with a platelet count of 29 x 103/μL (29 x 109/L).
|
test |
result |
|
PT |
12.1 seconds (11.4-13.5 seconds) |
|
aPTT |
32.6 seconds (25-35 seconds) |
The CBC RBC morphology shows schistocytes. The differential diagnosis should include:
One of the main difference between TTP and HUS is:
Several hours after birth an infant develops petechiae, purpuric hemorrhages and a platelet count of 21 x 103/μL (21 x 109/L). The most likely diagnosis is:
In TTP, a deficiency of ADAMTS13 causes clotting because of:
An orthopedic patient who is on heparin has a platelet count of 50 x 103/μL (50 x 109/L);his platelet count the previous day was 120 x 103/μL (120 x 109/L). The patient is tested for HIT and has a positive result. The first step in the treatment of HIT is:
In HELLP syndrome patients present with:
von Willebrand factor serves as a stabilizer for:
The platelet disorder in which the abnormality is due to a defect in platelet aggregation is: