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Unregulated and excessive formation of thrombin and plasmin is seen in:
A patient presents with a factor VIII level of 2%. The vWF activity (ristocetin cofactor) is<1% with a vWF antigen of 3%. The most likely diagnosis is:
A patient with a clot presents with the results shown in this table:
test |
result |
reference range |
PT |
15.5 seconds |
10.5-12.5 seconds |
aPTT |
50.3 seconds |
24-34.0 seconds |
D-dimer |
1.62mg/L |
<1.10mg/L |
fibrinogen |
35 mg/dL |
180-400 mg/dL |
fibrinogen antigen |
268 mg/dL |
150-350 mg/dL |
The most likely diagnosis is:
The following results are obtained on a pregnant woman who is short of breath.
test |
result |
reference range |
protein C activity |
62% |
70-120% |
protein S activity |
50% |
62-145% |
vWF activity |
199% |
>50% |
vWF antigen |
192% |
50-150% |
factor VIII |
189% |
50-150% |
The patient’s obstetrician calls because of concern about the patient’s clotting risk. Based on the pregnancy status of this patient, the results appear:
A 65-year-old male with metastatic pancreatic carcinoma shows elevated PT and aPTT, platelet count 15 x 103/μL (15 x 109/L) and elevated D-dimer. A blood smear would show:
A 25-year-old male with celiac disease presents with occult positive stools. What vitamin deficiency should be considered?
vWF antigen can be found in which of the following?
The life span of a platelet is:
Aspirin affects platelet function by interfering with platelet metabolism of:
In patients who present with bleeding disorders caused by platelets, the most common type of bleeding is:
The anticoagulant that is best directed against platelets is:
How do ticlopidine and clopidogrel inhibit platelets?
von Willebrand factor mediates platelet adhesion by binding to platelet receptor:
The disease state that presents with a quantitative platelet disorder is:
A patient presents with a very low platelet count and is diagnosed with acute idiopathic thrombocytopenic purpura (ITP). Which statement is associated with acute ITP?
The most common cause of bleeding in patients is:
A 53-year-old man is in recovery following a triple bypass operation. Oozing is noted from his surgical wound. The laboratory data shown in this table are obtained:
test |
result |
hemoglobin |
12.5 g/dL(125 g/L) |
hematocrit |
37% |
prothrombin time |
12.3 seconds |
aPTT |
34 seconds |
platelet count |
40.0 x 103/μL (40.0 x 109/L) |
fibrinogen |
250mg/dL (2.5g/L) |
The most likely cause of bleeding would be:
ADAMTS13 deficiency is responsible for thrombocytopenia found in:
Heparin induced thrombocytopenia (HIT) is an immune mediated complication associated with heparin therapy. Antibodies are produced against:
In polycythemia vera, the platelet count is: