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Question 1 of 20
1. Question
An 89-year-old Caucasian female is transferred to the hospital from a nursing facility for treatment of chronic urinary tract infection with proteinuria. The patient presents with the laboratory results shown in this table:
test
result
WBC
10.0×103/μL(10.0×109/L)
RBC
3.1×106/μL(3.1×1012/L)
HGB
7.2g/dL(72 g/L)
HCT
24%
MCV
78μm3(78fL)
MCH
23 pg
MCHC
31%
serum iron
29μg/dL(5.2μmol/L)
TIBC
160 μg/dL(28.6 μmol/L)
serum ferritin
100ng/mL(100μg/L)
These data are most consistent with which of these clinical conditions?
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Question 2 of 20
2. Question
A patient is admitted with a history of chronic bleeding secondary to peptic ulcer. Hematology results reveal a severe microcytic, hypochromic anemia. Iron studies are requested. Which result set would be expected in this case?
result
serum iron
TIBC
storage iron
a
decreased
increased
increased
b
increased
decreased
increased
c
decreased
increased
decreased
d
increased
normal
decreased
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Question 3 of 20
3. Question
Which of the following is most closely associated with iron deficiency anemia?
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Question 4 of 20
4. Question
Evidence indicates that the genetic defect in thalassemia usually results in:
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Question 5 of 20
5. Question
A 20-year-old African-American man has peripheral blood changes suggesting thalassemia minor. The quantitative HbA2 level is normal, but the HbF level is 5% (normal <2%). This is most consistent with:
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Question 6 of 20
6. Question
Anemia secondary to uremia and chronic renal disease characteristically is:
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Question 7 of 20
7. Question
Which of the following sets of laboratory findings is consistent with hemolytic anemia?
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Question 8 of 20
8. Question
Deficiency of this enzyme is associated with a moderate to severe hemolytic anemia after the patient is exposed to certain drugs and characterized by red cell inclusions formed by denatured hemoglobin:
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Question 9 of 20
9. Question
Patients with G6PD deficiency are least likely to have hemolytic episodes in which of the following situations?
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Question 10 of 20
10. Question
A patient has a congenital nonspherocytic hemolytic anemia. After exposure to anti-malarial drugs, the patient experiences a severe hemolytic episode. This episode is characterized by red cell inclusions caused by hemoglobin denaturation. Which of the following conditions is most consistent with these findings?
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Question 11 of 20
11. Question
Which of the following is the most characteristic finding in autoimmune hemolytic anemia:
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Question 12 of 20
12. Question
Peripheral blood smears from patients with untreated pernicious anemia are characterized by:
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Question 13 of 20
13. Question
Laboratory tests performed on a patient indicate macrocytosis and pancytopenia. Which of the following disorders is most likely?
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Question 14 of 20
14. Question
A patient has the laboratory results shown in this table:
test
result
RBC
2.35 x 106/μL (2.35×1012/L)
WBC
3.0 x 103/μL (3.0×109/L)
PLT
95.0 x 103/μL (95.0×109/L)
HGB
9.5 g/dL (115 fL)
HCT
27%
MCV
115μm3 (115fL)
MCHC
35%
MCH
40pg
Which of the following tests would contribute toward the diagnosis?
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Question 15 of 20
15. Question
The characteristic morphologic feature in folic acid deficiency is:
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Question 16 of 20
16. Question
A 50-year-old patient is found to have the laboratory result shown in this table:
test
result
HGB
7.0g/dL (70g/L)
HCT
20%
RBC
2.0 x 106/μL (2.0×1012/L)
It is determined that the patient is suffering from pernicious anemia. Which of these sets of results is most likely to have been obtained from the same patient?
Result
WBCs
platelets
reticulocytes
a
17,500
350,000
5.2%
b
7,500
80,000
4.1%
c
5,000
425,000
2.9%
d
3,500
80,000
0.8%
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Question 17 of 20
17. Question
Megaloblastic asynchronous development in the bone marrow indicates which one of the following?
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Question 18 of 20
18. Question
Which of the following are found in association with megaloblastic anemia?
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Question 19 of 20
19. Question
Which of the results represents characteristic features of iron metabolism in patients with anemia of chronic inflammation?
result
serum iron
transferrin saturation
TIBC
a
normal
normal
normal
b
increased
increased
normal or slightly increased
c
normal
markedly increased
normal
d
decreased
decreased
normal or decreased
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Question 20 of 20
20. Question
A characteristic morphologic feature in hemoglobin C disease is:
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