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An 89-year-old Caucasian female is transferred to the hospital from a nursing facility for treatment of chronic urinary tract infection with proteinuria. The patient presents with the laboratory results shown in this table:
test |
result |
WBC |
10.0×103/μL(10.0×109/L) |
RBC |
3.1×106/μL(3.1×1012/L) |
HGB |
7.2g/dL(72 g/L) |
HCT |
24% |
MCV |
78μm3(78fL) |
MCH |
23 pg |
MCHC |
31% |
serum iron |
29μg/dL(5.2μmol/L) |
TIBC |
160 μg/dL(28.6 μmol/L) |
serum ferritin |
100ng/mL(100μg/L) |
These data are most consistent with which of these clinical conditions?
A patient is admitted with a history of chronic bleeding secondary to peptic ulcer. Hematology results reveal a severe microcytic, hypochromic anemia. Iron studies are requested. Which result set would be expected in this case?
result |
serum iron |
TIBC |
storage iron |
a |
decreased |
increased |
increased |
b |
increased |
decreased |
increased |
c |
decreased |
increased |
decreased |
d |
increased |
normal |
decreased |
Which of the following is most closely associated with iron deficiency anemia?
Evidence indicates that the genetic defect in thalassemia usually results in:
A 20-year-old African-American man has peripheral blood changes suggesting thalassemia minor. The quantitative HbA2 level is normal, but the HbF level is 5% (normal <2%). This is most consistent with:
Anemia secondary to uremia and chronic renal disease characteristically is:
Which of the following sets of laboratory findings is consistent with hemolytic anemia?
Deficiency of this enzyme is associated with a moderate to severe hemolytic anemia after the patient is exposed to certain drugs and characterized by red cell inclusions formed by denatured hemoglobin:
Patients with G6PD deficiency are least likely to have hemolytic episodes in which of the following situations?
A patient has a congenital nonspherocytic hemolytic anemia. After exposure to anti-malarial drugs, the patient experiences a severe hemolytic episode. This episode is characterized by red cell inclusions caused by hemoglobin denaturation. Which of the following conditions is most consistent with these findings?
Which of the following is the most characteristic finding in autoimmune hemolytic anemia:
Peripheral blood smears from patients with untreated pernicious anemia are characterized by:
Laboratory tests performed on a patient indicate macrocytosis and pancytopenia. Which of the following disorders is most likely?
A patient has the laboratory results shown in this table:
test |
result |
RBC |
2.35 x 106/μL (2.35×1012/L) |
WBC |
3.0 x 103/μL (3.0×109/L) |
PLT |
95.0 x 103/μL (95.0×109/L) |
HGB |
9.5 g/dL (115 fL) |
HCT |
27% |
MCV |
115μm3 (115fL) |
MCHC |
35% |
MCH |
40pg |
Which of the following tests would contribute toward the diagnosis?
The characteristic morphologic feature in folic acid deficiency is:
A 50-year-old patient is found to have the laboratory result shown in this table:
test |
result |
HGB |
7.0g/dL (70g/L) |
HCT |
20% |
RBC |
2.0 x 106/μL (2.0×1012/L) |
It is determined that the patient is suffering from pernicious anemia. Which of these sets of results is most likely to have been obtained from the same patient?
Result |
WBCs |
platelets |
reticulocytes |
a |
17,500 |
350,000 |
5.2% |
b |
7,500 |
80,000 |
4.1% |
c |
5,000 |
425,000 |
2.9% |
d |
3,500 |
80,000 |
0.8% |
Megaloblastic asynchronous development in the bone marrow indicates which one of the following?
Which of the following are found in association with megaloblastic anemia?
Which of the results represents characteristic features of iron metabolism in patients with anemia of chronic inflammation?
result |
serum iron |
transferrin saturation |
TIBC |
a |
normal |
normal |
normal |
b |
increased |
increased |
normal or slightly increased |
c |
normal |
markedly increased |
normal |
d |
decreased |
decreased |
normal or decreased |
A characteristic morphologic feature in hemoglobin C disease is: