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A breakdown product of hemoglobin is:
Hemoglobin S can be separated from hemoglobin D by:
On electrophoresis at alkaline pH, which of the following is the slowest migrating hemoglobin?
The hemoglobin that is resistant to alkali (KOH) denaturation is:
The bilirubin results shown in the table are obtained on a patient:
day result
Given that the controls are within range each day, what is a probable explanation for the result on day 4?
Urobilinogen is formed in the:
In bilirubin determinations, the purpose of adding a concentrated caffeine solution or methyl alcohol is to:
If the total bilirubin is 3.1 mg/dL (53.0 μmol/L) and the conjugated bilirubin is 2.0 mg/dL (34.2 μmol/L), the unconjugated bilirubin is:
The principle of the tablet test or bilirubin in urine or feces is:
Ten heparinized plasma samples are assayed for bilirubin by Jendrassik-Grof method on analyzer 1,and by the Evelyn-Malloy method on analyzer 2, in a method comparison study.
The results are all 10-20% higher from analyzer 2 most likely because:
Serial bilirubin determinations performed by Jendrassik-Grof method are shown in this table:
day |
collected |
assayed |
result |
1 |
7 AM |
8 AM |
14.0mg/dL(239.4 μmol/L) |
2 |
7 AM |
6 PM |
9.0 mg/dL(153.9 μmol/L) |
3 |
6 AM |
8 PM |
15.0 mg/dL (256.5 μmol/L) |
The best explanation for the results is:
In the liver, bilirubin is converted to:
In which of the following disease states is conjugated bilirubin a major serum component?
Kernicterus is an abnormal accumulation of bilirubin in:
In which of the following conditions does decreased activity of glucuronyl transferase result in increased unconjugated bilirubin and kernicterus in neonates?
A 21-year-old man with nausea, vomiting, and jaundice has these laboratory findings:
test |
patient value |
reference range |
total serum bilirubin |
8.5mg/dL (145.4 μmol/L) |
0-1.0mg/dL(0.0-17.1 μmol/L) |
conjugated serum bilirubin |
6.1 mg/dL (104.3 μmol/L) |
0-0.5mg/dL (0.0-8.6 μmol/L) |
urine urobilinogen |
increased |
|
fecal urobilinogen |
decreased |
|
urine bilirubin |
positive |
|
AST |
300 U/L |
0-50 U/L |
alkaline phosphatase |
170 U/L |
0-150 U/L |
These can best be explained as representing:
A stool specimen that appears black and tarlike should be tested for the presence of:
What substance gives feces its normal color?
A condition in which erythrocyte protoporphyrin is increased is:
The definitive diagnosis for hereditary coproporphyria (HCP) is a markedly increased: