Pathology Part 2

A 32-year-old female was noted to have a breast mass with axillary lymph node enlargement. Further work ups revealed that the mass was cancerous. A diagnosis of invasive ductal carcinoma was made. Modified radical mastectomy was done with axillary lymph node dissection. Pathological examination of the axillary lymph nodes will show?

A 32-year-old male was admitted due to fatigue, unexplained fever and spontaneous mucosal and cutaneous bleeding lasting for about 2 weeks. Laboratory work ups revealed anemia, neutropenia and thrombocytopenia. Peripheral blood smear examination revealed a red staining peroxidase-positive structures with abnormal azurophilic granules. What is the possible diagnosis to this case?

A presence of necrosis with nuclear changes involving basophilia of the chromatin which later on fades or dissolves is called?

A 58-year-old female presented to the emergency department due to severe chest pain and diaphoresis. CK MB was elevated and Trop I was positive. ST segment elevation was noted in the ECG. On the 3rd hospital day, patient went into CHF accompanied by bilateral Grade 2 edema. What is the most probable etiology of the edema of this patient?

A 64-year-old female was a known case of DM Type II. Futher work ups upon admission revealed elevated Creatinine and BUN. What is/are the expected morphology, if her kidney will be examined pathologically?

A 59-year-old man is hospitalized after suffering a severe myocardial infarction. He is initially treated with nitrates, B blockers, and ASA and subsequently undergoes cardiac catheterization with placement of two stents. Following the procedure he is hemodynamically stable without recurrence of chest pain. However, 6 days after admission his heart rate is 134/min, BP is 70/30 mmHg and RR is 29 cpm. PE reveals distant heart sounds and an elevated jugular venous pressure. Which of the following complications is most likely causing this patient’s symptoms?

A 5-year-old female presents with a new onset hematuria and oliguria after 1 week of experiencing sore throat. Other pertinent findings revealed hypertension, periorbital edema and impaired renal function. A renal biopsy most likely would reveal electron-dense deposits in which of the following sites?

Which of the following colorectal polyps has the highest risk of malignant degeneration?

For the past year, a 48-year-old woman has noted that her menstrual periods have been exceptionally heavy and last 7 – 9 days. She has noted occasional minor intermenstrual bleeding. For the past 3 months, she has been taking supplemental dietary iron for IDA. On pelvic examination, the uterine cervix appears normal, but the uterus is enlarged to twice its normal size. Transvaginal ultrasound reveals the presence of a 9 cm solid mass in the uterus. A hysterectomy is performed, and on gross inspection with sectioning the uterus, a reddish-tan mass is found with fleshy cut surface. Microscopically, the mass is highly cellular, with spindle cells having hyperchromatic nuclei and 10-20 mitoses per high power field. Which of the following is the most likely diagnosis?

A 40-year-old male suddenly experienced severe headache. Upon consultation, his BP is noted to be at 200/120. History shows normal BP on regular checkups. Anti-hypertensive are immediately given. However, BP remains in the range of 200/120-180/100. Nicardipine drip is instituted. Two days later, the patient died because of intracerebral hemorrhage. Biopsy of the kidney revealed onion skin, concentric, laminated thickening of the walls of arterioles with progressive narrowing of the lumina consistent with what kind of arteriolosclerosis?

A patient with hemoptysis and renal failure has a renal biopsy which reveals crescentic glomerulonephritis, with linear deposits of IgG and C3 on immunofluorescence. What is the probable diagnosis?

A 1 year old patient came in due to fever. On physical examination, you noticed that the patient has epicanthal folds, flat facial profile, macroglossia and presence of simian crease. Further history revealed that the patient was born from a 48 year old mother. What is the most common cause of this chromosal disorder?

A 5-year-old male developed a demyelinating neuropathy associated with Campylobacter jejuni. He presents clinically with ascending neuromuscular paralysis and areflexia. He was then treated with plasmapheresis, IV immunoglobulins and corticosteroids. The diagnosis to this case belongs to what type of hypersensitivity?

What is the most common and the most severe form of LUPUS NEPHRITIS?

A 23-year-old female seek consult due to recurrent pyogenic infections caused mainly by staphylococci and streptococci. Further work up revealed that she is suffering from an autosomal recessive disease characterized by a failure of phagolysosomal fusion. Moreover, faulty microtubules was found to impair neutrophil chemotaxis. What is the most likely diagnosis?

Which of  the  following  disease-malignancy  association  is INCORRECT?

Cachexia is an irreversible catabolic reaction (wasting syndrome) common to those individual suffering from malignancies and tuberculosis. Which of the following substances is correlated to the pathophysiology of cachexia?

Beta HCG is a tumor marker for?

A 65-year-old male immigrant from Africa presents to the emergency department after an episode of gross hematuria. He states that he has seen small amounts of blood in his urine from time to time over the past several months. His physical examination is remarkable only for mild hepatosplenomegaly. A urology consult is called, and the urologist performs a bedside cytoscopy. A large fungating mass is seen adherent to the superior part of the bladder. What is the most likely environmental exposure associated with this disease in the patient?

Glanzmann thrombasthenia is a deficiency of?